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She Blinded Me with Science!!! Part Nineteen:Safeguarding Orthobiologic Treatments: The Impact of Low Glycemic Diets

Updated: Apr 2

By Deborah Westergaard, MD

Pain Experts

Regenexx Plano





In a world where high-fructose diets are the norm, understanding the impact of our dietary choices on orthobiologic treatments is crucial. Recent research sheds light on how elevated blood glucose levels, common in diets rich in simple carbohydrates, could hinder the healing processes facilitated by such treatments.


Understanding the Impact: The study, The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells - PubMed (nih.gov). reveals that high glucose environments can significantly impair the function and healing potential of mesenchymal stem cells, fundamental to orthobiologic recovery. Elevated glucose levels lead to reduced cell proliferation, increased apoptosis, and diminished stem cell abilities.


Why High Blood Sugar is Detrimental: At a molecular level, high blood sugar disrupts vital cellular functions, leading to poorer outcomes in regenerative treatments. This imbalance can compromise the effectiveness of orthobiologic procedures, impacting patient recovery.

This can affect lumbar disc degeneration. as evidenced by the article.

This study highlights that diabetes mellitus exacerbates intervertebral disc degeneration due to the adverse effects of high glucose on cell biology. Specifically, nucleus pulposus-derived mesenchymal stem cells (NPMSC) cultured in high glucose environments show reduced proliferation, colony formation, migration, and wound healing, along with decreased expression of stemness genes and other critical proteins, while exhibiting increased apoptosis and senescence. Stemness genes are those that encode for proteins involved in maintaining these defining stem cell properties.



These findings underscore the importance of managing high glucose levels in Diabetic patients to mitigate  intervertebral disc degeneration progression, suggesting early glucose control could be crucial in preventing or limiting the condition.



Significance to Patients and Physicians: For patients investing in their health through orthobiologic treatments, adhering to a low glycemic diet might not just be beneficial—it's essential. Providers can play a pivotal role in educating patients on the importance of dietary choices to optimize treatment outcomes.


Call Pain Experts to find out more: For those seeking to maximize the benefits of their orthobiologic treatments, consider a consultation with Pain Experts Orthobiologics in Dallas or Regenexx Plano in Plano. Texas.



Embracing a low glycemic diet could be a key step in protecting your health investment and ensuring the success of your regenerative treatments.





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               Deborah Westergaard, MD

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